OBJECTIVE： To investigate the effects of intensive insulin therapy on related indexes of stress diabetes patients with multiple trauma. METHODS： 82 stress diabetes patients with multiple trauma were randomly divided into observation group and control group， with 41 cases in each group. Two groups were given specific processing. Observation group was additionally given biosynthetic human insulin therapy with 1-2 IU/h drops of micro pump， adjusting dripping speed of micro pump according to real-time blood glucose value. Control group was given metformin hydrochloride tablets， with a meal， the initial dose of 0.5 g， twice a day， adjusting the dose of glucose-lowering drugs according to blood glucose value， increasing the dose to 1 g， twice a day. Both groups were treated for 10 d. CRP， TNF-α， IL-1， IL-6， average blood glucose were observed in 2 groups before and after treatment. The occurrence of complications as local infection， sepsis and SIRS were compared between 2 groups. RESULTS： After treatment， the serum levels of CRP， TNF-α， IL-1， IL-6，average blood glucose in 2 groups were significantly lower than before，and the serum level of CRP，IL-1，IL-6 in observation group after 5， 10 d of treatment and the serum level of TNF-α，average blood glucose after 1， 5， 10 d of treatment was significantly lower than control group at same time， with statistical significance （P＜0.05）. The incidence of complications in observation group after multiple trauma was significantly lower than control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Based on routine treatment，intensive insulin therapy can more effectively reduce the levels of blood glucose and inflammatory factors and prevent the occurrence of complications after multiple trauma，moreover，do not increase the occurrence of ADR.