OBJECTIVE： To study the formulation of Xiqingguo buccal tablet， optimize the proportion and quantity of main materials. METHODS： Using appearance， hardness， dissolution and taste as investigation indexes， orthogonal design was adopted to optimize the proportion and quantity of main thinner （lactose， mannitol）， wetting agent （ethanol）， lubricant （magnesium stearate）， flavoring agent （aspartame）， and critical relative humidity was detected. RESULTS： By wet granulation， the optimal formulation were as follows as the ratio of lactose and mannitol was 1 ∶ 3， ethanol volume fraction was 60％， the dosage of menthol， magnesium stearate， aspartame and orange essence was 0.4％， 0.9％， 2.0％， 0.4％； it was proven that the total score of 3 batches of samples were 2.67， 2.67， 2.70 （RSD＝0.65％， n＝3）， respectively. The critical relative humidity of granule was 60％. CONCLUSIONS： The Xiqingguo buccal tablet prepared by optimal prescription meets the requirements.