OBJECTIVE: To investigate the utilization of the most used splitting drugs in the inpatients of our hospital, and to promote rational use of splitting drugs. METHODS: The medical orders of oral tablets in the inpatients of our hospital in Jan. 2016 were analyzed statistically in respects of consumption quantity, classification dosage, department dosage and the proportion of scored tablets. RESULTS & CONCLUSIONS: There were 217 389 medical orders of tablets in the inpatients of our hospital in Jan. 2016. There were 12 792 medical orders of splitting drugs, with utilization rate of 5.88%. The most used splitting tablet were cardiovascular drugs and drug for nervous system, accounting for 53.31% and 20.72% of total. The splitting tablets were mostly used in respiratory and critical care medicine department. Top 10 departments in the list of the number of splitting drug medical orders prescribed 8 993 splitting drug medical orders, accounted for 70.30% of total. Top 20 drugs in the list of the number of splitting drugs were involved in 8 971 medical orders, accounting for 70.13% of total; there were 14 kinds of scored drugs and 7 506 medical orders of splitting scored drugs, accounting for 83.67% of top 20 medical orders of splitting drugs. Among splitting drugs, 49 types had scored-line, which were prescribed in 9 265 medical orders of splitting drug, accounting for 72.43% of all medical orders of splitting drug. Lacking of information in most package inserts about the tablet can or can not split, it is suggested to note this information in package inserts by pharmaceutical enterprises. For commonly used splitting drugs without scored-line, it is proposed to produce small-size drugs or add scored-line.