OBJECTVE： To investigate the clinical effect and safety of pregabalin combined with gabapentin in the treatment of central pain after cerebral infarction. METHODS： One hundred and fifty patients with central pain after cerebral infarction in our hospital from Jan. 2010 to Dec. 2015 in our department were randomly divided into group A， B， C ， with 50 cases in each group. Group A was given Pregabalin capsule 75 mg， bid combined with Gabapentin capsule 0.1 g， tid； group B was given Pregabalin capsule 75 mg， bid； group C was given Gabapentin capsule 0.1 g， tid； 3 groups were treated for 4 weeks. VAS score， NRS score， PSQI and SF-36 score were observed among 3 groups before and after treatment to evaluate clinical efficacies of 3 groups； the occurrence of ADR were recorded in 3 groups. RESULTS： The clinical total response rate of group A， B， C were separately 94.00％， 74.00％， 70.00％. The clinical total response rate of group A was significantly better than that of group B and C， with statistical significance （P＜0.05）. After treatment， VAS score of group A， B， C were separately（3.87±0.74），（5.10±1.26），（5.03±1.23）； NRS score were separately （3.91±0.88），（5.29±1.25），（5.37±1.30）； VAS score and NRS score of group A were significantly lower than group B， C and before treatment， with statistical significance （P＜0.05）； PSQI score of group A， B， C were separately（4.03±0.85），（5.92±1.16），（5.83±1.11）； SF-36 score  were separately （372.84±73.25），（348.07±60.54），（345.67±59.72）； PSQI score and SF-36 score of group A were significantly better than group B， C and before treatment， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR among 3 groups （P＞0.05）. CONCLUSIONS： Compared with pregabalin and gabapentin alone， pregabalin combined with gabapentin in the treatment of central pain after cerebral infarction can efficiently relieve the perceived pain， improve sleep quality and daily life quality and not increase the risk of ADR； therefore， drug combination plan is recommended for patient with central pain after cerebral infarction， especially with poor effect of two single drug.