OBJECTIVE： To observe the effects of Compound biejia ruangan tablets combined Entecavir tablets on liver function and hematoidin of patients with chronic hepatitis B （CHB） blood stasis syndrome. METHODS： Totally 110 patients with CHB blood stasis syndrome were selected from Neijiang Second People’s Hospital， the Affiliated Hospital of Southwest Medical University and Yibin First People’s Hospital during Jan.-Dec. 2015. They were divided into control group and observation group by stratified blocked randomitation， with 55 cases in each group. Control group was given Entecavir tablets 0.5 mg，po，qd； observation group was additionally given Compound biejia ruangan tablets 2.0 g， po， tid. Both groups received treatment for 12 months. TCM syndrome scores， the levels of liver function indexes （AST， ALT， ALP， GGT）， serum bilirubin （TBIL， DBIL， IBIL）， liver fibrosis indexes （LN， HA， PⅢP， Ⅳ-C） and Fibroscan （FS） were observed in 2 groups before and after treatment. The occurrence of ADR was recorded. RESULTS： In observation group， 2 patients withdrew from the study， and 3 patients of control group withdrew from the study. Before treatment， there was no statistical significance in TCM syndrome scores， the levels of liver function indexes， serum bilirubin， liver fibrosis indexes and FS between 2 groups （P＞0.05）. After treatment， TCM syndrome scores， the levels of TBIL， IBIL， LN， HA， PⅢP， Ⅳ-C and FS in 2 groups were significantly decreased， while DBIL level was increased significantly， and the observation group was significantly better than control group， with statistical significance （P＜0.05）. The levels of AST and ALT in observation group were decreased significantly， while the levels of ALP and GGT were increased significantly， and the observation group was significantly better than control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between observation group （9.09％） and control group （10.91％） （P＞0.05）. CONCLUSIONS： For CHB blood stasis syndrome， Compound biejia ruangan tablets combined with Entecavir tablets can improve liver function indexes and bilirubin level， and inhibit liver fibrosis with good safety.