OBJECTIVE： To investigate the effects and safety of Sophora flavescens preparation combined with Fuzheng huayu capsule on hepatic hemodynamics and fibrosis indexes in patients with hepatitis B liver cirrhosis. METHODS： One hundred and two patients diagnosed as hepatitis B liver cirrhosis in our hospital during Feb. 2013-Jun. 2014 were divided into combination group and control group according to random number table， with 51 cases in each group. Control group was treated with Adefovir dipivoxil capsules 10 mg， po， qd； combination group was additionally given Fuzheng huayu capsules 1.5 g， po， tid+Sophora flavescens preparation （Matrine glucose injection 250 mL， ivgtt， qd， in the first 3 months， oxymatrine capsules 200 mg， po， tid， after 3 months） on the basis of control group. Both groups were treated for 12 months. The levels of HBV-DNA， liver function indexes （AST， ALT， TBIL），portal hemodynamic indexes [main portal vein inner diameter （D）， mean blood flow velocity （V）] and liver fibrosis indexes [laminin protein （LN）， hyaluronic acid （HA）， type Ⅳ collagen （Ⅳ-C）] were observed in 2 groups before and after treatment. The negative conversion rate of HBV-DNA and incidence of ADR were recorded. RESULTS： Three cases lost to follow up， and a total of 48 effective cases were included in control group； 5 cases lost to follow up， and a total of 46 effective cases were included in combination group. Before treatment， there was no statistical significance in HBV-DNA levels， liver function indexes （AST， ALT， TBIL）， liver fibrosis indexes （LN， HA， Ⅳ-C） and portal vein hemodynamic indexes （D， V） between 2 groups （P＞0.05）. After treatment， above indexes of 2 groups were decreased significantly， and the combination group was significantly lower than the control group， with statistical significance （P＜0.05）. The negative conversion rate of HBV-DNA in combination group was 93.5％， which was significantly higher than 79.2％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Sophora flavescens preparation combined with Fuzheng huayu capsules can promote the recovery of liver function， regulate liver hemodynamics and alleviate hepatic fibrosis in patients with hepatitis B liver cirrhosis with good safety.