OBJECTIVE： To observe the effectiveness and safety of Jin’s three-needle combined with Jiawei wumei pill in the treatment of menopausal insomnia. METHODS： One hundred and sixty-five patients with perimenopausal insomnia were selected from our hospital during Jan. 2015-Mar. 2016， and then divided into group A （n＝41）， group B （n＝41）， group C （n＝41） and group D （n＝42） according to random number table. Group A was given Estazolam tablet 1 mg， qd； group B was given Jin’s three-needle 30 min/time， qd； group C was given Jiawei wumei pill， one pill， after breakfast and supper warm taking； group D was given Jin’s three-needle combined with Jiawei wumei pill with same usage as group C. Four groups were treated for 4 weeks. PSQI score， modified Kupperman score， life quality score， serum levels of E2 and FSH were observed in 4 groups before and after treatment， and the occurrence of ADR was recorded. RESULTS： Before treatment， there was no statistical significance in above score （P＞0.05）. After treatment， PSQI score and modified Kupperman score of 4 groups were decreased significantly， compared to before treatment； the group B， C， D were significantly lower than the group A； the group D was significantly lower the group B， C， with statistical significance （P＜0.05）. The life quality score of 4 groups were increased significantly， and the group B， C， D were significantly higher than the group A； the group D was significantly higher than the group B， C， with statistical significance （P＜0.05）. E2 level of group B， C， D were significantly increased， while FSH level was decreased significantly， the improvement of group D was significantly better than group B， C； the improvement of group D was significantly better than that of group B， C， with statistical significance （P＜0.05）. The incidence of ADR in group A was significantly higher than group B， C， D， with statistical significance （P＜0.01）， and there was no statistical significance in the incidence of ADR among group B， C， D， with statistical significance （P＞0.05）. CONCLUSIONS： Jin’s three needle combined with Jiawei wumei pill is effective in the treatment of perimenopausal insomnia with good safety.