OBJECTIVE： To explore the present situation of scientific research of clinical pharmacists in domestic third-grade class A hospitals， and discuss its feasible research ideas. METHODS： Questionnaire was conducted for the scientific research situation of clinical pharmacists who obtained the certification in domestic 63 third-grade class A hospitals， the questionnaire data was collected， and data was statistically analyzed by using IBM SPSS Statistics 22.0 software. RESULTS： Totally 315 questionnaires were sent out， 282 were effectively received， with effective recovery of 89.52％. In terms of attitude to scientific research， proportion of the surveyed clinical pharmacists who thought it was quite necessary and necessary was more than 70％； except for academic degree（P＜0.05）， the different gender， age and job title did not cause the differences in scientific research attitude （P＞0.05）. In terms of the present situation of scientific research， achievements of them were relatively simple， thinking the biggest difficulty was insufficient of experiment condition； there was significant difference in the numbers of authorized patents in recent 5 years by different gender （P＜0.05）， the numbers of applications for approved funds， authorized patents and paper published in recent 5 years by different academic degrees （P＜0.05）， as well as the numbers of applications for approved off-campus funds （title also related to the number of hospital funds） and the numbers of paper published in domestic magazine in recent 5 years by different ages and job titles （P＜0.05）. In terms of direction of scientific research， most of surveyed clinical pharmacists thought they should strengthen communicate with physicians and look for the breakthrough point， they also thought the optimal one was clinical research； the direction selection was basically similar no matter the gender， academic degree， age and job title （P＞0.05）. In terms of ability enhancement， the surveyed pharmacists thought literature review， evidence-based literature/experimental interpretation and foreign language reading were the abilities most need to be enhanced； except for gender， academic degree， age and job title showed similarity in enhancing the literature review， evidence-based literature/experimental interpretation ability （P＞0.05）， while there were significant differences in enhancing foreign language reading ability by different gender， academic degree， age and job title （P＜0.05）. CONCLUSIONS： Clinical pharmacists show certain differences in the attitude to scientific research， present situation and direction of scientific research， and ability enhancement because of different gender， academic degree， age and job title， but there are also common. In order to improve the competence of scientific research and promote the discipline development of clinical pharmacy， pharmacy administrator in hospital should improve the academic degree and job title on clinical pharmacists and provide necessary advanced scientific platform and pertinent training at the same time. Additionally， except for the rational drug use， evidence-based pharmacy and pharmacoeconomics， clinical pharmacists can find new breakthrough point from pharmaceutical care， drug treatment decisions， translational medicine and medicine large data.