OBJECTIVE： To develop the drug traceability management system in outpatients of medical institutions， and gradually improve its traceability management. METHODS： Based on barcode technology， drug traceability management system in outpatients of medical institutions was independently developed， introducing it from system environment， framework design and system function， and the application results were evaluated in terms of differences in dispensing time， deployment error， drug withdrawal treatment and applicability investigation. RESULTS： The system was developed on hospital information system network environment， which was designed by combination of client/server （C/S） network system （B/S） and set function modules as follows as role rights management， data extraction， information control， data acquisition and data query. The system can match with drug electronic surveillance code， commodity code and other traceable barcodes， achieve drug tracing from hospitals to users through software interaction， as well as the computer-aided calibration in dispensing to effectively reduce outpatient’s dispensing error. The average time for each outpatient prescription prolonged 9 s after using the system； 24 dispensing errors and 4 non-normal withdrawals were prevented within 1 month； 100％ surveyed pharmacists expressed approval for the system’s applicability. CONCLUSIONS： The system can achieve the drug suitability management in outpatients， which has shown good applicability and further improved drug safety management and control capabilities in medical institutions.