OBJECTIVE： To explore therapeutic efficacy and safety of Puerarin injection for elderly female patients with osteoporosis and unstable angina pectoris， and its effects on serum inflammatory factors. METHODS： Totally 107 elderly women with osteoporosis and unstable angina were analyzed retrospectively and divided into control group （53 cases） and observation group （54 cases） according to drug use. Control group was given routine treatment as Caltrate D， Alendronate sodium tablet，Glyceryl trinitrate tablet ，Metoprolol tartrate tablet，Atorvastatin calcium tablet，Trimetazidine hydrochloride tablet. On the basis of control group， observation group was additionally given Puerarin injection 4 mL added into 5％ Glucose injection 500 mL intravenously， once a day. Treatment course of 2 groups lasted for 2 weeks. Therapeutic efficacies of 2 groups were observed as well as the levels of serum inflammatory factors （hs-CRP， TNF-α， MMP-9， sCD40L）， and the occurrence of ADR. RESULTS： The total response rates of angina pectoris and osteoporosis pain in observation group were significantly higher than control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in serum inflammatory factors as hs-CRP， TNF-α， MMP-9， sCD40L between 2 groups （P＞0.05）. After treatment， the levels of hs-CRP， TNF-α， MMP-9 and sCD40L in 2 groups were significantly lower than before， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Based on routine treatment， Puerarin injection shows significant therapeutic efficacy for senile female osteoporosis patients with unstable angina and can significantly reduce the levels of serum inflammatory factors with good safety.