OBJECTIVE： To explore the effects of xingnaojing combined with naloxone on related indexes of patients with hepatic encephalopathy. METHODS： In retrospective analysis， 76 patients with hepatic encephalopathy were divided into control group （40 cases） and observation group （36 cases） according to drug use. Based on routine treatment， control group was additionally given Naloxone injection 1 mg added into 10％ Glucose solution 100 mL intravenously twice a day. Observation group was additionally given Xingnaojing injection 20 mL added into 0.9％ Sodium chloride injection 250 mL intravenously once a day on the basis of control group. Treatment courses of 2 groups lasted for 2 weeks. HDS score， MMSE score， the levels of blood ammonia， β-endorphin， CRP， IL-6 and TNF-α， the occurrence of ADR were observed in 2 groups before and after treatment. RESULTS： After treatment， HDS score and MMSE score of 2 groups were significantly higher than before treatment， and the observation group was significantly higher than the control group； the levels of blood ammonia， β-endorphin， IL-6， CRP and TNF-α in 2 groups were significantly lower than before treatment， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the level of IL-10 between 2 groups before and after treatment （P＞0.05）. There was no statistical significantly in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS：Based on routine treatment， Xingnaojing combined with naloxone can significantly improve cognitive function for patients with hepatic encephalopathy and reduce peripheral blood neurotoxin and inflammatory factor， moreover， do not increase the incidence of ADR.