OBJECTIVE： To provide reference for rational use of antihypertensive drugs in the clinic. METHODS： One hundred and eighteen primary hypertensive inpatients were selected from our hospital during Jan.2014-Oct.2015. The application of antihypertensive drugs and medication compliance were summarized and analyzed by reviewing the doctor’s advice and the questionnaire survey method. RESULTS： Commonly used antihypertensive drugs of our hospital included diuretic， β receptor blocker， calcium antagonist， angiotensin converting enzyme inhibitor， angiotensinⅡreceptor antagonist and aldosterone receptor antagonist. Among 118 patients， fewer patients treated with monotherapy（10 cases， 8.47％）， and three-drug regimen took up the greatest proportion （51 cases， 43.22％）. The number of patients receiving antihypertensive drugs in related internal medicine departments （94 cases） was more than in related surgical departments （24 cases）. 25 patients used antihypertensive drugs irrationally， mainly from internal medicine department， heart disease department， cerebropathy department， etc. Irrational medication mainly included irrational frequencies （8 cases， 32.00％）， pharmaceutical frame structure damage （5 cases， 20.00％）， irrational drug selection （4 cases， 16.00％）， etc. The poor medication compliance was found in 16 patients， mainly resulted from complex therapy plan （6 cases， 37.50％）， forgetting to take medicine （5 cases， 31.25％）. CONCLUSIONS： Irrational use of antihypertensive drugs exist in primary hypertensive inpatients of our hospital. Clinical pharmacists should use their own advantage to strengthen communication with medical staff， develop in pharmaceutical care and promote rational drug use in the clinic.