OBJECTIVE： To prepare the Albendazole nanoliposomes freeze-dried power and study its properties. METHODS： Freeze-drying method was conducted to prepare Albendazole nanoliposomes freeze-dried power， using the particle size， encapsulation efficiency， appearance， redispersibility as indexes， single factor test was combined with orthogonal test to screen freeze-drying preparation technology. The morphological changes， particle size， Zeta potential， moisture content， 12 months stability at 4 ℃ before and after freeze-drying were detected. RESULTS： Plus a total content of freeze-dried protective agent was 10％， the ratio of glucose-trehalose-mannitol was 1.0 ∶ 1.0 ∶ 3.0， using quick-freeze， pre-freezing 18 h in －35 ℃ refrigerator， dry-freezing 48 h to obtain freeze-dried powder. Compared with before freeze-drying， the freeze-dried liposomal morphology had no obvious changes， showing clear phospholipid bilayer membrane structure； the particle sizes before and after freeze-drying were （208.63±1.04） nm and （223.04±2.02） nm， Zeta potentials were （－15.6±0.04） mV and （－19.4±0.06） mV， encapsulation efficiencies were （94.62±0.49）％ and （91.10±0.46）％ （n＝3）， respectively. Compared with liposomes， liposomes freeze-dried power had good stability in 12 months at 4 ℃. CONCLUSIONS： Albendazole nanoliposomes freeze-dried power is prepared successfully， its stability is superior to albendazole nanoliposomes， and the freeze-drying technology is feasible.