OBJECTIVE： To provide reference for rational use of antibiotics to treat Pseudomonas aeruginosa （PA） infection in the clinic. METHODS： Resistant rate of PA in our hospital during 2011-2015 were analyzed retrospectively. Antibiotics use density （AUD） of 10 commonly used antibiotics were analyzed statistically， and the correlation of resistant rate with AUD was investigated by Spearman correlation analysis. RESULTS： One thousaud and eleven strains of PA were isolated in our hospital during 2011-2014， detection rate of PA always occupied the top 5 place. Top 3 antibiotics in the list of AUD were levofloxacin， ceftazidime， cefoperazone sodium and tazobactam sodium. AUD of piperacillin sodium and tazobactam sodium， levofloxacin， ciprofloxacin and meropenem were positively correlated with resistant rate of PA （r were 1.000， 0.900， 1.000， 1.000， P＜0.05）. AUD of cefoperazone sodium and tazobactam sodium were negatively correlated with resistant rate of PA （r＝－0.900，P＜0.05）. AUD of imipenem and cilastatin sodium， ceftazidime， gentamicin， aztreonam and amikacin had no correlation with resistant rate of PA （P＞0.05）. CONCLUSIONS： There is correlation between AUD of antibiotics and resistant rate of PA. It is of important significance to detect resistant rate of PA and the use of antibiotics regularly. Antibiotics should be selected cautiously in accordance with bacterial monitoring data， results of drug sensitivity tests， the amount and resistant rate of antibiotics， etc， in order to reduce resistant PA.