OBJECTIVE： To establish the UPLC fingerprint for Qinghou liyan granule， and provide reference for its quality control by combining with principal component analysis （PCA）. METHODS： UPLC was performed on the column of ACQUITY UPLC BEH C18 with mobile phase of acetonitrile （A）-0.1％ aqueous phosphoric acid solution （B） （gradient elution） at a flow rate of 0.4 mL/min， the detection wavelength was 280 nm， column temperature was 30 ℃， and injection volume was 2 μL. Using ellagic acid as a reference， 12 batches of samples were analyzed， “Similarity Evaluation Software for Chromatographic Fingerprint of Traditional Chinese Medicine” was used for the similarity analysis and identification of the common peaks， and the PCA was used for common peaks. RESULTS： There were 18 common peaks in the fingerprints of 12 batches of samples， and 6 principal peaks （gallic acid， ellagic acid， naringin， hesperidin， neohesperidin and baicalin） were identified； the similarity degree of 12 batches and reference fingerprints were no less than 0.984. According to PCA， the 18 peaks can be integrated into 3 principal components， with cumulative contribution rate of principal component of 78.277％； baicalin and 16 peaks were the discriminating factors of the fingerprint of Qinghou liyan granule. CONCLUSIONS： The method can provide reference for the quality control of Qinghou liyan granule.