OBJECTIVE： To provide reference for the informational and automatic management in Pharmacy intravenous admixture service （PIVAS）. METHODS： The composition and practical application of PIVAS automatic management system developed in our hospital were introduced， and ratio of irrational medical order， drug dispensing efficiency and the numbers of error before and after application were compared to evaluate its effect. RESULTS & CONCLUSIONS： The work process was intelligently optimized， PIVAS automatic management system developed in our hospital composed by automatic prescription audit system， intelligent drug dispensing system， intelligent liquid preparation system， automated sorting system and automatic transportation system， which respectively achieved the automated audit of prescription， intelligent drug dispensing and labeling， responsibility traced in drug dispensing， intelligent mixed deployment of intravenous infusion， automated sorting and transportation of finished products of transfusion liquid. The ratio of irrational medical order decreased from 2.07％ to 1.73％， time of drug dispensing and labeling shortened from （3.15±0.53） h to （1.55±0.27） h， numbers of error within daily dispensing decreased from 0.26±0.78 to 0.06±0.13， numbers of error within daily sorting of finished products of transfusion liquid decreased from 6.57±1.76 to 0.07±0.17. The construction of the system achieves the information and automation of major work in PIVAS and improves the management level of PIVAS.