OBJECTIVE： To evaluate the control efficacy of details thinking management on the infusion microne in pharmacy intravenous admixture services （PIVAS）. METHODS： One thousaud and two hundred infusion information dispensed by PIVAS and 150 inpatients were collected from our hospital during Jan.-Dec. 2014 （before implementation group） and Jan.-Dec. 2015 （after implementation group）. The number of suspended particles and sedimentated bacteria in different levels of clean area in PIVAS， the number of particles in dispensed infusion and the occurrence of ADR caused by infusion particles were compared before and after the implementation of details thinking management as strengthening working system， improving the quality of staff， implementing management during whole process， etc. RESULTS： After the implementation of details thinking management， the number of suspended particles and sedimentated bacteria in different levels of clean area were decreased significantly compared to before implementation， with statistical significance （P＜0.05）. The number of particles ≥10 μm and ≥25 μm among electrolyte， TCM injection and  digestive system agents infusion， the number of particles ≥10 μm among antibiotics infusion and the number of particles ≥25 μm among vitamin infusion were all decreased significantly compared to before implementation； the number of rubber and glass particles among dispensed infusion were decreased significantly with statistical significance （P＜0.05）. The incidence of ADR as blood vessel blockage， edema， phlebitis and heat source reaction were all decreased compared to before implementation， with statistical significance （P＜0.05）. CONCLUSIONS： The implementation of details thinking management can improve clean degree of different levels of clean area in PIVAS， and reduce the number of particles in various dispensed infusion so as to improve the quality of dispensed infusion to certain extent and guarantee the safety of drug use.