OBJECTIVE： To optimize the decoction technology of Zhuanggufang decoction powder. METHODS： Central composite design with 2 factors and 5 levels was conducted to design the test， taking water （fold） and decoction time as independent variables， the extraction amount of icariin and extraction yield overall desirability value of as dependent variables， regression equation were fitted； response surface method was used to optimize the decoction technology of Zhuanggufang decoction powder， and was verified. It was compared with the traditional decoction piece effect. RESULTS： The optimized technology was decocted twice with 16-fold water， 20 min each time； relative error of predicted and theoretical value by overall desirability value was 2.97％； after decoction powder and piece decocted in the same conditions， the extraction amounts of icariin were 1.234 3 μg/g and 1.132 4    μg/g， extraction yields were 23.73％ and 17.84％， respectively. CONCLUSIONS： Central composite design-response surface method optimizing decoction technology is simple and reliable， the optimized decoction technology is stable and feasible， and the decoction capability of Zhuanggufang decoction powder is better than the traditional pieces.