OBJECTIVE： To provide reference for rational application of tigecyclinet and alert to the occurrence of severe ADR. METHODS： Fifity patients receiving tigecycline in a level 3 general hospital during 2013-2015 were analyzed retrospectively to observe the change of symptom， sign and lab indexes after using Tigecyclinet injfection. Possible ADR of tigecycline， processing and outcomes were summarized. RESULTS： Among 50 patients， there were 24 cases of ADR， including 10 cases of inducing or aggravating blood coagulation abnormality （41.67％）， 9 cases of liver function injury （37.50％）， 4 cases of vomiting and other gastrointestinal discomfort （16.67％）， 1 case of red erythra with itching （4.17％）. ADR of digestive system were mild and recovered after symptomatic treatment as inhibiting acid， antiemetic. Severe ADR as Liver function injury could not be recovered after symptomatic treatment as protecting liver， reducing enzyme. Nine cases of liver function injury mainly manifested as the elevation of TBIL， DBIL， ALP， LDH； 8 of which suffered from liver function injury before medication and the symptom was aggravated after medication； liver function injury appeared in 3 cases on 10th day after medication and in 2 cases on 9th day after medication. Ten cases suffered from coagulation function disorder before medication and the symptom was aggravated after medication， which mainly manifested as the prolongation of APTT and TT and the elevation of INR， PT， D-dimer， etc. The coagulation function disorder was aggravated abnormally on 2nd-22th day after using tigecycline， mainly appearing on 2nd-5th day （70.00％）. CONCLUSIONS： Great importance should be attached to severe ADR as coagulation function disorder， liver function injury when using tigecycline， in order to ensure the safety of drug use.