OBJECTIVE： To provide reference for promoting clinical rational application of Xueshuantong for injection （lyophilized）. METHODS： By hospital centralized monitoring method， all medical records were retrieved from Hospital Information System of our hospital， who received Xushuantong for injection （lyophilized） from Aug. 7 to Oct. 6 in 2015； general information of patients’ drug information，drug utilization and the occurrence of ADR were traced and recorded by clinical pharmacists to evaluate the rationality of clinical utilization of  Xushuantong for injection （lyophilized）. RESULTS： Totally of 1 014 medical records were included in the study. Xueshuantong for injection （lyophilized） was mainly used for fracture， cerebral infarction， coronary disease， cataract and other disease. 22 clinical departments as orthopedics department， neurology department， cardiology department and ophthalmology department were involved， accounting for 56.41％ of total. For the patients receiving Xushuantong for injection （lyophilized）， the average age was 63.12 years， the average course was 11 days and dose was 100-500 mg/time. They were given medicine intravenously once a day， and 0.9％ Sodium chloride injection was used as solvent （93.29％）. There were 10 kinds of drugs for drug combination averagely. The incidence of ADR was 5.92‰， and all ADR resulted from same batch of drugs （No. 15040211）； ADR mainly manifested as erythra， erythema， pruritus， chills， etc. In terms of irrational drug use， the incidence of overlong treatment course was 17.85％； that of inadequate solvent dose was 13.71％； that of fast dripping rate was 7.59％； that of unsuitable solvent selection was 0.69％； that of drug use with no indication was 0.39％. CONCLUSIONS： Xueshuantong for injection （lyophilized） is widely used in middle-aged and elderly in the clinic. There are many varieties and irrational drug use. The occurrence of ADR is properly related to age， treatment course， solvent， dripping speed， product quality and other factors. Clinical pharmacists are required to monitor drug use， promote the rationality of drug use and reduce the occurrence of ADR.