OBJECTIVE： To provide reference for rational use of anticoagulant drugs in the clinic. METHODS： Medical orders of anticoagulant drugs were collected from hospital information system of our hospital during 2013-2015. Those medical orders were analyzed in respects of consumption sum， DDDs， DDC and drug utilization. RESULTS： During 2013-2015， the sum tatio of Low-molecular-weight heparins calcium injection（6 000 AXaIU），Enoxaparin sodium injection（6 000 AXaIU）， Dalteparin sodium injection（5 000 IU） and Rivaroxaban tablets（10 mg）were on the rise，while those of Nadroparin calcium infection（6 150， 4 100 AXaIU） and Fondaparinux sodium injection（2.5 mg） were in the decline. DDDs of Nadroparin calcium injection （4 100 AXaIU）， Dalteparin sodium injection （5 000 IU） and Enoxaparin sodium injection （6 000 AXaIU） took up the first 3 places. DDC of Rivaroxaban tablets was the highest， being 167.60-180.25 yuan. The utilization of Nadroparin calcium injection（6 150， 4 100 AXaIU），Low-molecular-weight heparins calcium injection （6 000 AXaIU）， Fondaparinux sodium injection（2.5 mg） and Warfarin sodium tablets（3 mg） showed good synchronization within 3 years， and the values of B/A ranged 0.50-1.50. Both consumption sum and utilization rate of rivaroxaban took up the first place in vascular surgery department. CONCLUSIONS： Based on the spectrum of diseases， the features of drugs and ADR， the utilization of anticoagulant drugs in our hospital is rational during recent 3 years. However， the utilization of anticoagulant drugs should be still used as routine pharmaceutical monitoring content.