OBJECTIVE： To analyze the safety of linezolid （LZD） for elderly patients， and probe into the regularity of adverse reaction （ADR）.  METHODS： In retrospective study， elderly patients treated with LZD injection or tablets were selected from our hospital during Jan. 2014-Dec. 2015. The occurrence of ADRs were analyzed statistically. RESULTS： A total of 126 patients were included， the age was from 65 to 94 year-old， and the mean duration of treatment was （9.47±6.31） d （ranged 1-35 d）. Forty-five cases suffered from ADR after medication （35.71％）， followed by 39 cases of thrombocytopenia （30.95％）， 9 cases of leukocytopenia（7.14％）， 7 cases of hemoglobin reduction （5.55％）， 6 cases of nausea and vomiting （4.76％）， 4 cases of transaminase elevation （3.17％）， 4 cases of diarrhea （3.17％）， 2 cases of lactic acidosis （1.59％）， 2 cases of skin rash （1.59％） and 1 case of drug fever （0.79％）. The incidence of thrombocytopenia in ICU patients was significantly higher than non-ICU patients， with statistical significance （P＝0.019）. There was no significant difference among different dosage forms of LZD without statistical significance（P＝0.218）. CONCLUSIONS： Clinicians and pharmacists should closely monitor the application of LZD in elderly patients， pay more attention to ADR induced by LZD， especially in ICU， it induces the high incidence of thrombocytopenia. Meanwhile， it is suggested to monitor serum lactate concentrations regularly during treatment.