OBJECTIVE： To investigate the effects of using oxycodone hydrochloride before abdominal closure on hemodynamics and sedation in gynecological patients underwent general anesthesia of laparoscopic surgery. METHODS： Eighty-two patients undergoing gynecological laparoscopic surgery were selected and divided into control group and observation group according to treatment order， with 41 cases in each group. Both group were operated under general anesthesia with endotracheal intubation. Observation group was given oxycodone hydrochloride intravenously 3 mg， and control group was given constant volume of 0.9％ Sodium chloride injection before abdominal closure. SBP， HR and Ramsay score were observed in 2 groups during extubation （T1）， 5 min after extubation （T2）， 30 min after extubation （T3）. The spontaneous breathing recovery time， recovery time， extubation time and the occurrence of cough and agitation were recorded in 2 groups. 2， 4， 6 and 24 h after surgery， VAS scores were determined in 2 groups. The occurrence of ADR was observed in 2 groups. RESULTS： At T1 and T2， there was no statistical difference in SBP and HR between 2 groups （P＞0.05）； at T3， SBP and HR of control group were significantly increased and higher than observation group， with statistical significance （P＜0.05）； At T1， there was no statistical significance in Ramsay score between 2 groups （P＞0.05）； at T2 and T3， Ramsay score of observation group was significantly improved and higher than control group， with statistical significance （P＜0.05）. There was no statistical significance in extubation time between 2 groups （P＞0.05）. The spontaneous breathing recovery time and recovery time of observation group were significantly shorter than control group， with statistical significance （P＜0.05）. The incidence of no cough and agitation at 0 level in observation group were significantly higher than in control group； and the incidence of median and severe cough， agitation at 2-3 level were significantly lower than control group， with statistical significance （P＜0.05）. 2 h， 4 h， 6 h and 24 h after operation， VAS scores of observation group were significantly lower than control group， with statistical significance （P＜0.05）. The incidence of ADR in observation group was 7.3％， which was significantly lower than 51.2％ of control group， with statistical significance （P＜0.05）. CONCLUSIONS： The application of oxycodone hydrochloride before abdominal closure shows good analgesic and sedative effects in gynecological laparoscopic surgery under general anesthesia with good safety， can keep hemodynamics stable and quick recovery.