OBJECTIVE： To optimize the extraction technology of Duoxuekang. METHODS： Using comprehensive score of salidroside， gallic acid content and extraction yield as indexes， U6（63） uniform design was designed to optimize the liquid-solid ratio， ethanol volume fraction and extraction time of Duoxuekang， then optimize extraction times， and verification test was conducted. RESULTS： The optimal extraction technology was as follows as 50％ ethanol， liquid-solid ratio of 1 ∶ 14， soaking time of 1.5 h， reflux extraction for 1 h and repeated twice； the average extraction yield in 3 tests was 50.18％， contents of salidroside and gallic acid were 1.82 mg/g， 16.54 mg/g （RSD≤0.84％， n＝3）. CONCLUSIONS： The optimized extraction technology for Duoxuekang is reasonable， simple and feasible.