OBJECTIVE： To systematically review the procalcitonin（PCT） -guided therapy in patients with sepsis. METHODS： Retrieved from PubMed， Cochrane Library， EMBase， CJFD， Wanfang Datebase， related trails about PCT-guided therapy（test group） versus conventional treatment group （control group） in the treatment of sepsis were collected. Meta-analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation. RESULTS： Totally 5 studies were enrolled， involving 826 patients. Results of Meta-analysis showed， use time of antibiotics in test group was significantly shorter than control group， with statistical significance [MD＝－2.52，95％CI（－3.07，－1.98，P＜0.001]； there were no significant differences in the mortality rate [OR＝1.14，95％CI（0.83，1.56），P＝0.42]， ICU treatment days [MD＝－0.22，95％CI（－1.40，0.96），P＝0.72] and total hospitalization [MD＝－1.81，95％CI（－4.37，0.76），P＝0.17]. CONCLUSIONS： PCT-guided therapy can effectively reduce the use of antibiotics and shorten treatment time in the treatment of patients with sepsis.It can be considered as inflammatory markers for guiding rational use of antibiotics in clinic.