OBJECTIVE： To investigate clinical efficacy of cerebroventricular perfusion and intrathecal perfusion of vancomycin assisting with continuous drainage in the treatment of intracranial infection secondary to traumatic brain injury， and its effects on cerebrospinal fluid indexes and intracranial pressure. METHODS： One hundred and eighty patients with  intracranial infection secondary to traumatic brain injury selected from Sanya Hospital of TCM during Jan. 2012 to Jun. 2015 were randomly divided into control group and observation group according to lottery， with 90 cases in each group. They were given cerebroventricular perfusion and intrathecal perfusion of vancomycin （20 mg dissolved in 5 mL normal saline） in cella lateralis and lumbar cisterna respectively combined with continuous drainage， q12 h. Both groups received treatment for 7 d.Clinical efficacy， the time of infection control were compared between 2 groups as well as body temperature， intracranial pressure and cerebrospinal fluid indexes before and after treatment， and the occurrence of ADR. RESULTS： After treatment， total response rate of observation group （95.56％） was significantly higher than that of control group （77.78％）， with statistical significance （P＜0.05）. The time of infection control in observation group [（9.67±1.10）d] was significantly shorter than in control group [（11.84±1.29）d]， with statistical significance （P＜0.05）. Body temperature， intracranial pressure， cerebrospinal fluid protein and leukocyte of 2 groups were significantly lower than before treatment； cerebrospinal fluid glucose level was increased significantly compared to before treatment； above indexes of observation group were significantly better than those of control group， with statistical significance （P＜0.05）.There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： The intrathecal perfusion of vancomycin assisting with continuous drainage in the treatment of intracranial infection secondary to traumatic brain injury can effectively speed up the rehabilitation process， reduce the body temperature and intracranial pressure， and is helpful to improve the relevant cerebrospinal fluid indexes. Therapeutic efficacy of it is better than that of cerebroventricular perfusion.