OBJECTIVE： To provide reference for informationized construction of outpatient narcotic drug management in the hospital. METHODS： The narcotic drugs management system， which consisted of the hospital information system and the intelligent management machine of narcotic drugs were introduced in working procedure and informationized management， and its effects were evaluated. RESULTS： After informationized construction， the recycling of empty ampoules and used patches was included in compulsory management procedure； informationized management would be achieved completely from safety management， prescribing and dispensing property management， prescription management， batch number management， outcoming and incoming management， “five special” management， etc. Compared with traditional dispensing mode， the dispensing time of each prescription was shortened under informationized dispensing mode， decreasing from （174±32.3） s to （128±30.7） s （P＜0.05）. Pharmacists could communicate with physicians online by the system； drug application， incoming， use， inventory reconciliation， special book for registration and special book of account were all completed by electronic recording and electronic registering； the system could automatically complete the report form of prescription information for evaluation. CONCLUSIONS： It is feasible of the informationized mode of outpatient narcotic drug management in our hospital.