OBJECTIVE： To investigate the effects of Yiqi huayu granules on gastrointestinal motility of  gastrointestinal motility disorder model mice and blood rheology of acute blood stasis model rats， and to provide experimental evidence for clinical use of it. METHODS： 50 ICR mice were randomly divided into normal group， model group， mosapride group （positive control chemical drug， 0.003 g/kg）， Muxiang shunqi pills group （positive control TCM， 0.36 g/kg） and Yiqi huayu granules group （2.4 g/kg）， with 10 mice in each group. Treatment groups were given relevant medicine solution intragastrically， once a day， for a week； normal group and model group were given normal saline intragastrically. Those groups fasted for 24 h after last medication， and then were given above medicine intragastrically； 1 h later， they were given atropine sulfate intragastrically to induce gastrointestinal motility disorder model except for normal control group. The stomach residue rate and intestinal propulsive rate of mice were measured. 60 SD rats were randomly divided into normal group， model group， Compound danshen tablet group （positive control， 1.0 g/kg） and Yiqi huayu granules high-dose， medium-dose and low-dose groups （2.4， 1.2， 0.6 g/kg）， with 10 rats in each group. Normal group and model group were given normal saline intragastrically， and treatment groups were given relevant medicine， once a day， for a week. 1 h after last medication， those groups were given adrenaline intraperitoneally+aqua astricta. to induce acute blood stasis model except for normal group. The whole blood viscosity （high-shearing， middle-shearing，low-shearing）， plasma viscosity， 1， 3， 5 min platelet aggregation rate ， hematocrit and maximal platelet aggregation rate were all detected in rats. RESULTS： Compared with normal group， stomach residue rate of mice in model group was increased significantly （P＜0.01）， while intestinal propulsive rate was decreased significantly （P＜0.01）. The whole blood viscosity （high-shearing， middle-shearing，low-shearing）， plasma viscosity， hematocrit， 1， 3， 5 min platelet aggregation rate and maximal platelet aggregation rate of rats were all increased significantly in model group （P＜0.01）. Compared with model group， above indexes of mice/rats were all improved significantly in treatment groups （P＜0.05 or P＜0.01）. CONCLUSIONS： Yiqi huayu granules can significantly promote the function of gastrointestinal peristalsis and anticoagulation.