OBJECTIVE： To study the effects of nimesulide combined with oxaliplatin on microvessel density and immune function of esophageal cancer model rats. METHODS： 48 rats were selected to establish esophageal cancer model and then randomly divided into model group， oxaliplatin group， nimesulide group and combination group， with 12 rats in each group. 1 d after modeling， model group was given 5％ Glucose injection 1 mL via tail vein， 3 times a week， and constant volume of Sodium carboxymethylcellulose solution， once a week. Oxaliplatin group was given oxaliplatin 13.6 mg/kg via tail vein， 3 times a week. Nimesulide group was given nimesulide 20 mg/kg intragastrically， once a week. Combination group was given oxaliplatin and nimesulide with same usage as above. The administration lasted for 8 weeks. The cancer growth， microvessel density of cancer tissue， peripheral blood immune function index were observed in four groups. RESULTS： Compared with model group， cancer size， cancer weight， integral absorbance of cancer and positive vessel density were all decreased in treatment groups （P＜0.05）. The number of peripheral blood CD3+， CD4+T cells and CD4+/CD8+ were all decreased in oxaliplatin group and combination group， while the number of CD8+T cells was decreased （P＜0.05）. Compared with nimesulide group， cancer size， cancer weight， integral absorbance of cancer， positive vessel density， the number of peripheral blood CD3+， CD4+T cells and CD4+/CD8+ were all decreased in oxaliplatin group and combination group， while tumor inhibition rate and the number of CD8+T cells were all increased （P＜0.05）； combination group was more significant than oxaliplatin group （P＜0.05）. CONCLUSIONS： Oxaliplatin combined with nimesulide can effectively inhibit cancer growth of esophageal cancer， the mechanism of which may be associated with inhibiting angiogenesis of tumor tissue and strengthening immune function.