OBJECTIVE： To compare the efficacy of structured fat emulsion and medium/long chain fat emulsion for nutritional support in liver carcinoma patients after hepatectomy. METHODS： 100 patients from our hospital during Jan. 2013 to Mar. 2016 with primary liver carcinoma were selected and divided into control group and observation group according to random number table， with 50 cases in each group. Control group was given Medium/long chain fat emulsion injection （C6-24）， and trial group was given Structured fat emulsion injection （C6-24）， by equal nitrogen and equal heat principles， via peripheral inserted central venous catheter， 16-18 h each day， for 7 d. The levels of ALT， AST， TBIL， PAB， ALB， TC， TAG， CRP were observed in 2 groups， and hospitalization time， complication and the occurrence of ADR were also recorded. RESULTS： Before treatment， there was no statistical significance in above indexes between 2 groups （P＞0.05）. On 5th，7th day of treatment， the levels of ALT， AST and TBIL of 2 groups were significantly higher than before treatment， but the levels of ALT， AST and TBIL of trial groups were significantly lower than those of control group， and the level of PAB of trial group was significantly higher than that of control group， with statistical significance （P＜0.05）； on 5th day of treatment， the levels of TC， TAG and CRP in trial group were significantly lower than in control group， with statistical significance （P＜0.05）.  Average postoperative hospitalization time of trial group was significantly shorter than that of control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of complication between 2 groups after surgery （P＞0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Compared to medium/long chain fat emulsion， structured fat emulsion can relieve the burden of liver metabolism and  inflammation reaction， improve nutritional status in liver carcinoma patients after hepatectomy with good safety.