OBJECTIVE： To observe the efficacy and safety of metoclopramide in the treatment of migraine. METHODS： 120 patients with migraine were randomly divided into observation group （60 cases） and control group （60 cases）. Control group received magnetic therapy， oxygen therapy， psychological counseling and maintaining healthy lifestyle and avoiding all kinds of migraine incentives， mild - moderate headache patients were given Paracetamol suspension drop 2.5 mg， orally， once a day， severe patients were given 2％ lidocaine hydrochloride injection 1 mg/kg+dexamethasone acetate injection 5 mg， intravenously injected within 2 min， once a day. Observation group was additionally given Metoclopramide tablet 10 mg， orally， once a day. The patients were treated for 14 d. Clinical efficacy， headache seizure frequency， headache seizure duration and degree score， hemorheology indexes before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， with statistical significance （P＜0.05）. After treatment， the headache seizure frequency， headache seizure duration and degree score， hemorheology indexes in 2 groups were significantly lower than before， and observation group was lower than control group， with statistical significance （P＜0.05）. And there was no significant difference in the incidence of adverse reactions （P＞0.05）. CONCLUSIONS： Based on the conventional treatment， metoclopramide shows good efficacy and safety in the treatment of migraine.