OBJECTIVE： To observe the effects of Yiqi huoxue fengjing capsules on the cerebral blood flow （CBF） and cerebral vascular resistance （CVR） in anesthetized dogs. METHODS： 18 Beagle dogs were randomly divided into sham operation group （purified water）， positive control TCM group [Naoxintong capsules， 0.3 g（crude drug）/kg]， positive control pharmaceutical chemicals group （nimodipine， 7×10－3 g/kg） and Yiqi huoxue fengjing capsules low-dose， medium-dose and high-dose groups [0.63， 1.26， 2.52 g（crude drug）/kg）]， with 3 dogs in each group. They were given relevant medicine via duodenum. CBF， CVR， blood pressure and heart rate of the dogs were measured before medication and 30， 60， 120 min after medication. RESULTS： 30， 60， 120 min after medication， CBF increased in positive control TCM group， positive control pharmaceutical chemicals group and Yiqi huoxue fengjing capsule high-dose group， while CVR decreased significantly in positive control pharmaceutical chemicals group and Yiqi huoxue fengjing capsules high-dose group， blood pressure and heart rate of positive control pharmaceutical chemicals group decreased， with statistical significance compared to sham operation group （P＜0.05 or P＜0.01）. CONCLUSIONS： Yiqi huoxue fengjing capsules can increase CBF and decrease CVR， and they have no effect on blood pressure and heart rate in anesthetized dogs.