OBJECTIVE： To observe the efficacy and safety of Yuanhu zhitong dropping pill combined with triple therapy in the treatment of recurrent abdominal pain in children with Hp infection. METHODS： 100 Hp infection children with recurrent abdominal pain were randomly divided into control group （50 cases） and observation group （50 cases）. Control group received Omeprazole enteric-coated tablet 0.5 mg/（kg·d）， twice a day+Amoxicillin capsule 50 mg/（kg·d）， orally， q8 h+Clarithromycin tablet 20 mg/（kg·d）， orally， twice a day [if someone was allergic to penicillin， then Metronidazole tablet 20 mg/（kg·d） was orally given， 3 times a day]. Observation group was additionally given 15 Yuanhu zhitong dropping pills with hot water， 3 times a day. The treatment course for 2 groups was 2 weeks. Clinical efficacy， Hp eradication rate， clinical symptom score before and after treatment and the incidence of adverse reactions in 2 groups were observed. RESULTS： 100 cases completed the treatment， no children lost to follow-up. Total effective rate， Hp eradication rate in observation group were significantly higher than control group， with statistic significance （P＜0.05）. Before treatment， there was no significant difference in clinical symptom score （P＞0.05）. After treatment， the clinical symptom scores in 2 groups were significantly lower than before， and observation group was lower than control group， with statistic significances （P＜0.05）. And there was no significant difference in the incidence of adverse reactions （P＞0.05）. CONCLUSIONS： Yuanhu zhitong dropping pill combined with triple therapy shows good efficacy and safety in the treatment of recurrent abdominal pain in children with Hp infection， it can improve the Hp eradication rate.