OBJECTIVE： To observe the efficacy and safety of Puerarin injection combined with amiodarone in the treatment of arrhythmia in patients with coronary heart disease （CHD） after CPI. METHODS： Date of 80 CHD patients with arrhythmia after PCI were retrospectively analyzed and divided into observation group （40 cases） and control group （40 cases） by different treatment methods. All patients in perioperative period and postoperative medication administrated according to the condition of AHA/ACC guidelines. Two groups were treated with conventional western medicine， based on it， control group received Amiodarone injection 150 mg， adding into 5％ Glucose injection 20 ml fully dissolved by slowly intravenous injection within 15 min， slowly intravenous injected with speed rate of 1 mg/min with load amiodarone of 3 mg/kg until disease had been eased， maintained 0.5 mg/min for 24 h of 1 200 mg after 6 h， intravenous infusion of Amiodarone injection for 3 d+oral administration of Amiodarone tablet 0.2 g， tid， reduced to 0.2 g after 1 week， bid. On the basis of control group， observation group received Puerarin injection 400 mg， adding into 0.9％ Sodium chloride injection 250 ml， intravenous infusion， once a day， and 2 groups were treated for 2 week. Clinical efficacy， heart rate （HR）， left ventricular ejection fraction （LVEF）， left ventricular end systolic diameter （LVESD） and left ventricular end-diastolic diameter （LVEDD） before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： The effective rate in observation group was significantly higher than control group， with statistical significance （P＜0.05）. Before treatment， there was no significant difference in the HR， LVEF， LVESD and LVEDD in 2 groups （P＞0.05）. After treatment， HR， LVESD and LVEDD were significantly lower than before， and observation group was lower than control group， LVEF was significantly higher than before， and observation group was higher than control group， with statistical significances （P＜0.05）. And there was no significant difference in the incidence of adverse reactions in 2 groups（P＞0.05）. CONCLUSIONS： The Puerarin injection combined amiodarone shows good efficacy in the treatment of CHD patients with arrhythmia after CPI， which can improve patients’ cardiac functions， does not increase the adverse reactions， with good safety.