OBJECTIVE： To provide reference for clinical pharmacists participating in anti-infection treatment for patients with purulent meningitis. METHODS： Medical records of 26 discharged patients with purulent meningitis in our hospital during Jan. 2010 to Dec. 2015 were analyzed retrospectively， the consultation of which clinical pharmacists participated in and which showed poor therapeutic efficacy. The data was summarized in respects of pathogen detection， preliminary anti-infection plan， consultation advice of clinical pharmacists， outcome， etc. RESULTS： Among 26 cases， 26 strains of pathogen were detected， mainly including Streptococcus pneumoniae  （7 strains）， Staphylococcus aureus  （5 strains）， Listeria monocytogenes  （4 strains）， Pseudomonas aeruginosa  （4 strains） and Acinetobacter baumannii  （2 strains）. There were many problems in preliminary anti-infection plan， such as not cover pathogen （11 cases， 42.31％）， irrational dosage and frequency of antibiotics （5 cases， 19.23％）， irrational drug combination （3 cases， 11.54％）， irrational drug selection （3 cases， 11.54％）， irrational treatment course （2 cases， 7.69％） and irrational route of administration （2 cases， 7.69％）. Clinical pharmacists provided consultation advise， such as combined with other antibiotics （10 cases， 38.46％）， adjusting the types of antibiotics （7 cases， 26.92％）， adjusting dosage and （or） frequency （5 cases， 19.23％）， changing route of administration （2 cases， 7.69％）， etc. After medication adjustment， 22 patients were recovered （Glasgow score of 5 points）. CONCLUSIONS： Clinical pharmacists analyze the pathogen by their professional knowledge， assist physicians to adjust and improve anti-infection plan for patients with purulent meningitis through consultation， and promote the clinical outcome of patients with poor efficacy after preliminary anti-infection treatment.