OBJECTIVE： To explore the reules and characleristics of ADR reduced by fluorouracil， capecitabine， epirubicin， cisplatin， irinotecan， paclitaxel， oxaliplatin and docetaxel for patients with gastric cancer. METHODS： The Chinese and English literatures about the reports of fluorouracil， capecitabine， epirubicin， cisplatin， irinotecan， paclitaxel， oxaliplatin and docetaxel in the treatment of gastric cancer were extracted， and statistical analysis was carried out for the included studies. RESULTS： Totally 306 were chosen，including 511 patients involving 663 cases. The ration of male to female was 1.30 ∶ 1，227 cases aged 41-60 years old （accounting for 48.19％），ADR mainly included gastrointestinal damage（273 cases， accounting for 41.18％）， cardiovascular system damage（156 cases，accounting for 23.5％），respiratory system（76 cases，accounting for 11.46％）， mainly fifth were nausea（82 cases）， vomiting（78 cases）， bone marrow suppression（69 cases）， diarrhea（52 cases） and digestive system reaotions（41 cases）. 49.90％ patients showed drug adverse reactions within 30 minutes， most patients were improved to heal. CONCLUSIONS： Prompt medical workers pay attention to patients age， sex， and the accumulative system in treatment with stomach cancer ， reduce the occurrence of adverse drug reactions.