OBJECTIVE： To explore the correlation between ornidazole （ONZ） salivary concentration and plasma concentrations in healthy subjects， and to provide reference for clinical therapeutic drug monitoring. METHODS： 24 healthy volunteers were selected. After oral administration of ONZ capsules 1.00 g， their venous blood and saliva were collected at 0.25， 0.5， 1.5， 5.5， 10.5， 24.5 and 43.5 h after medication. HPLC method was used to determine the plasma and salivary concentrations of ONZ. The correlation between the two was analyzed. RESULTS： The peak values of plasma and salivary ONZ concentrations appeared immediately at 1.5 h after administration and the peak values were （0.96±0.15） μg/ml and （0.93±0.15） μg/ml； salivary concentration of ONZ was lower than plasma concentration at each time points， but there was no statistical significance （P＞0.05）； the regression equation of salivary ONZ concentration and plasma concentration was csaliva＝1.176 5cplasma－0.199 4（r＝0.990 1）. The ratio of salivary concentration and plasma concentration of ONZ （S/P） was （0.91±0.06）， showing positive correlation （r＝0.632-0.970，P＜0.05）. CONCLUSIONS： The salivary ONZ concentration is significantly correlated with plasma concentration in healthy people， so saliva can be used for therapeutic drug monitoring.