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WANG Ting; XIONG Fen; TANG Hongmei; CHAI Yuna; HUANG Yusheng; LIU Yuan; ZHONG Rufan

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- China Pharmacy Vol. 27, Issue 35, (2016)
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WANG Ting, XIONG Fen, TANG Hongmei, et al. [J]. China Pharmacy 27(35).(2016)
DOI：

WANG Ting, XIONG Fen, TANG Hongmei, et al. [J]. China Pharmacy 27(35).(2016) DOI：

摘要

目的：比较喜炎平注射液与利巴韦林注射液治疗普通型儿童手足口病的成本-效果，为临床合理用药提供依据。方法：计算机检索中国知网、维普、万方、PubMed、Cochrane Library等数据库中关于喜炎平注射液治疗普通型儿童手足口病并以利巴韦林注射液为对照的研究文献，采用TreeAge Pro 2011构建决策树模型，对两种方案进行成本-效果分析，采用龙卷风图进行敏感因素分析并作单因素和双因素敏感度分析。结果与结论：喜炎平注射液和利巴韦林注射液治疗普通型儿童手足口病的总成本分别为2 887.53元和3 058.72元，总有效率分别为92.49％和78.12％，喜炎平注射液更具成本-效果优势。敏感度分析支持成本-效果分析结果。

Abstract

OBJECTIVE： To compare cost-effectiveness of Xiyanping injection and Ribavirin injection in the treatment of common type hand-foot-mouth disease （HFMD） in children， and to provide evidence for rational drug use in the clinic. METHODS： The literatures about Xiyanping injection in the treatment of common type HFMD in children using Ribavirin injection as control were retrieved from CNKI， VIP， Wanfang， PubMed， Cochrane library and other databases. The decision tree was established with TreeAge Pro 2011 software to conduct cost-effectiveness analysis. Tornado diagram was used to analyze sensitive factors； single factor and double factors sensitivity analysis were also conducted. RESULTS & CONCLUSIONS： The total cost of Xiyanping injection and Ribavirin injection were 2 887.53 and 3 058.72 yuan， respectively. The total effective rates were 92.49％ and 78.12％. Xiyanping injection shows cost-effectiveness advantage. The results of cost-effectiveness analysis were supported by sensitivity analysis.

关键词

决策树模型成本-效果分析喜炎平注射液利巴韦林注射液普通型手足口病儿童龙卷风图

Keywords

Decision tree modelCost-effectiveness analysisXiyanping injectionRibavirin injectionCommon type hand-foot-mouth diseaseChildrenTornado diagram

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Laboratory of Child Development and Disorder,National Clinical Research Center for Child Health and Disorders(Chongqing),China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Pediatrics,Children’s Hospital of Chongqing Medical University

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