OBJECTIVE： To study the inhibitory effect of ethyl acetate part from Ferula sinkiangensis on S180 solid tumor in mice．METHODS： 60 mice were randomly divided into normal control group， tumor model group， ethyl acetate part of F. sinkiangensis low-dose， middle-dose and high-dose groups （1.0， 2.0， 3.0 g/kg，ig）， cisplatin control group （positive drug， 5 mg/kg，iv）， with 10 mice in each group. Except for normal control group， other groups were given mice ascites infected by S180 solid tumor to induce S180 solid tumor model. The next day after modeling， those groups were given relevant medicine， and normal control group and tumor model group were given constant volume of normal saline， once a day， for consecutive 10 days. Body weight， organ （spleen， thymus） index， the change of tumor volume， volume and weight of solid tumor， inhibitory rate of tumor and pathological change were observed in each group. ELISA method was used to determined the serum levels of IL-2， IFN-γ and TNF-α. RESULTS： Compared with normal control group， spleen index and TNF-α of tumor model group were increased significantly， while IL-2 and IFN-γ were decreased significantly （P＜0.05）； dysplastic cells of tumor tissue appeared lumpy， accompanied by a number of ischemic necrosis of dysplastic cells. Compared with tumor model group， body weight， spleen index， thymus index and volume and weight of solid tumor in cisplatin control group were decreased significantly， while IL-2 and TNF-α levels were increased significantly. The spleen index and TNF-α level of ethyl acetate part of F. sinkiangensis groups were increased significantly， while the volume and weight of solid tumor were decreased significantly （P＜0.05）. The tumor tissue was inhibited to different extents， especially in cisplatin control group； the number of tumor cells was decreased， accompanied by small number of cellular necrosis and infiltration. Inhibitory rates of cisplatin control group， ethyl acetate part of F. sinkiangensis groups were （73.26±4.55）％，（40.34±3.45）％，（50.86±9.34）％，（58.20±3.70）％， respectively. CONCLUSIONS： ethyl acetate part of F. sinkiangensis can inhibit S180 solid tumor in mice.