OBJECTIVE： To obverse the efficacy and safety of  Liuwei dihuang pill combined with TCM prescription acupoint application in the treatment of type 2 diabetic constipation. METHODS： 120 patients with type 2 diabetic constipation were randomly divided into control group （60 cases） and observation group （60 cases）. All patients received controlling blood pressure and regulating blood lipids drugs， diet control combined with exercise， and fixed dose of Metformin hydrochloride tablet（0.5 g/times，2 times a day） and Acarbose tablet（100 mg/times，3 times a day）； based on it， control group received 5 mg Mosapride citrate tablet， 3 times a day； observation group additionally received 8 Liuwei dihuang pills （3 times a day） combined with TCM prescription acupoint application （in double Tianshu Point， double Yongquan point， double Shenque Point and double Zusanli）. 7 d was regarded as a treatment course， and it lasted 3 courses. Clinical efficacy， blood glucose [2 h postprandial glucose （2 h PG）， blood glucose （FPG）]， the clinical symptom indexes （defecation interval time， each defecation time， weekly defecation frequency） before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than in control group，and the difference was statistically significant （P＜0.05）. Before treatment， there were no significant differences in the 2 h PG， FPG， defecation interval time， each defecation time and weekly defecation frequency between 2 groups （P＞0.05）. After treatment， 2 h PG and FPG in 2 groups were significantly lower than before， and observation group was lower than control group； defecation interval time and each defecation time were significantly shorter than before， and observation group was shorter than control group； weekly defecation frequency was significantly higher than before， and observation group was higher than control group， The differences were statistically significant （P＜0.05）. During treatment， 6 patients showed adverse reactions in control group， and 5 in observation group， and there was no significant difference in the incidence of adverse reactions between 2 groups （P＞0.05）. CONCLUSIONS： Liuwei dihuang pill combined with TCM priscription acupoint application shows good efficacy in the treatment of type 2 diabetic constipation. It can effectively improve constipation， reduce defecation interval time and each defecation time， increase weekly defecation frequency and have no influence on blood glucose control with small adverse reactions and high safety.