OBJECTIVE： To optimize water extraction and granulating technology of Tongmai granule. METHODS： Using the contents of notoginsenoside R1， ginsenoside Rg1， ginsenoside Re and ginsenoside Rb1 and yield of extracts as the index， L9（34） orthogonal design was used to optimize and validate water extraction technology in preparation process of Tongmai granule. Decontamination， concentration and drying， diluent of granulating technology were investigated. RESULTS： The optimal water extraction technology was as follows as 8-fold water， soaking for 0.5 h， decocting 1.0 h each time， for 2 times. In validation test， the yield of extract was （28.38±0.461）％ （RSD＝1.63％，n＝3）， and the content of total saponins was （5.029±0.060） mg/g （RSD＝1.20％，n＝3）. The optimized granulating technology was that extract was filtrated and decontaminated， and then concentrated under vacuum degree of 0.08 MPa and vacuum temperature of 60 ℃； the ratio of extraction powder-accessories （maltodextrin） was 3 ∶ 1， drying temperature was set at 85-90 ℃； the amount of diluent was 3％. Under this condition， the content of total saponins was （5.211±0.207） mg/g （RSD＝3.96％，n＝3） . CONCLUSIONS： This technology is stable and feasible， and it is suitable for the preparation of Tongmai granule.