OBJECTIVE： To systematically review the efficacy and safety of Bushen huoxue herb and celecoxib in the treatment of knee osteoarthritis， and provide evidence-based reference for clinical treatment. METHODS： Retrieved from CNKI， CBM， VIP and Wanfang Database， Medline， PubMed and Cochrane Library， randomized controlled trials （RCT） about Bushen huoxue herb （test group） and celecoxib（control group） in the treatment of knee osteoarthritis were collected. Meta-analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation. RESULTS： Totally 15 RCTs were included， involving 1 129 patients. Results of Meta-analysis showed， the total effective rate [RR＝1.09，95％ CI（1.04，1.14），P＜0.01] and visual ache （VAS） score [MD＝－0.49，95％CI（－0.94，－0.03）， P＜0.05] in test group were significantly higher than control group， the differences were statistically significant； there was no significant difference in knee function score [Lequesne：MD＝0.24，95％CI（－1.20， 1.68），P＞0.05； Lysholm： MD＝2.32，95％CI（－1.95，6.58），P＞0.05； WOMAC： MD＝－2.87，95％CI（－6.38， 0.64），P＞0.05] and the incidence of adverse reactions in 2 groups[RR＝0.49，95％CI（0.22，1.09），P＝0.08]. CONCLUSIONS： Bushen huoxue herb shows better efficacy and analgesic effect than celecoxib in the treatment of knee osteoarthritis， and is similar to celecoxib in terms of improving knee function score and safety.