OBJECTIVE： To optimize the water extraction technology of Jianpi yishen pills. METHODS： Using water amount， extraction time and extraction times as factors， the content of salvianolic acid B and dry extract amount as index， orthogonal test was employed to optimize the extraction technology of Jianpi yishen pills. RESULTS： The optimal extraction technology was extracting twice， adding 12-fold water for the first time， 8-fold water for the second time， extracting for 1 h each time. Average comprehensive score of validation test was 95.5 （RSD＝0.52％， n＝3）. CONCLUSIONS： The optimized technology is simple， suitable and stable， and can be used for the extraction and preparation of Jianpi yishen pills.