OBJECTIVE： To introduce briefly the job responsibilities and position of clinical pharmacist in the United States and provide experiences for developing clinical pharmaceutical care practice of in China. METHODS： The evolving mode of pharmaceutical care practice in the United States were introducted descriptively， and the job responsibilities and contents of clinical pharmacists and future perspectives were described. RESULTS & CONCLUSIONS： In the United States， clinical pharmacists gradually participate in drug therapy management since they provided pharmaceutical care for patients in early 1920’s. Multiple studies confirmed that the participation of clinical pharmacists can reduce ADR and hospitalization risk， and improve therapeutic efficacy and satisfactory degree. The job responsibilities of pharmacists mainly include management， clinic， teaching and scientific research， etc. The job contents include checking the doctor’s advice， offering patient care and pharmaceutical ward round， carrying out medication reconciliation， medication record and medication education， undertaking relative research including basic medicine and clinical and management. In the future， the field of clinical pharmacists will transform from inpatient department to outpatient department and family healthcare service. The pattern of pharmacy practice in the United States can offer valuable experiences and references to pharmaceutical care in China.