OBJECTIVE： To optimize the extraction technology of Compound Selaginella moellendorffii powder. METHODS： The amount of water， extracting time and times were screened by orthogonal test using the content of 6-C-β-D-glucopyranosul-8-C-β-D-xylopyranosyl apigonin （YⅡ） and astilbin， the yield of extract as index. The validation test was conducted. RESULTS： The optimal extraction technology was as follows as 12-fold water， decocting 3 times， 1 h each time； in validation test， the content of YⅡand astilbin were 0.350 6 mg/g （RSD＝1.207 4％， n＝3） and 1.406 0 mg/g （RSD＝1.459 8％， n＝3）； the yield of extract was 23.066 6％ （RSD＝1.660 3％， n＝3）. CONCLUSIONS： The technology is reasonable and scientific， and can be used for the extraction of Compound S. moellendorffii powder.