OBJECTIVE： To explore the clinical efficacy and safety of Compound danshen dropping pill combined with aspirin in the treatment of coronary heart disease （CHD）. METHODS： 120 CHD patients were divided into control group and observation group by random number table method， with 60 cases in each group. Based on routine treatment as ACEI， low molecular heparin， β receptor block and nitric acid ester， control group was additionally given Aspirin enteric coated tablet orally， 100 mg each time， qd； observation group was additionally given Compound danshen dripping pills orally， 270 mg each time， tid， on the basis of control group. Treatment of 2 groups lasted for 6 months. Clinical efficacy and ECG efficacy were observed in 2 groups. The changes of platelet parameters， heart function indexes， lung function indexes and SYNTAX score of coronary artery were detected in 2 groups before and after treatment， and the occurrence of ADR was observed. RESULTS： After treatment， the effective rates of clinical efficacy and ECG efficacy in observation group were significantly higher than in control group （95.0％ vs.76.67％， 71.67％ vs.51.67％）， with statistical significance （P＜0.05）. The platelet maximum aggregation rate， plasma thromboxane B2， mean platelet volume， left ventricular end systolic diameter and left ventricular end diastolic diameter of observation group were significantly lower or less than those of control group； the cardiac output， left ventricular ejection fraction， first second forced respiratory volume， F EV％， diffusing capacity of pulmonary carbon monoxide of observation group were significantly higher than those of control group， with statistical significance （P＜0.05）； SYNTAX score of observation group was significantly lower than that of control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Compound danshen dripping pills combined with aspirin in the treatment of CHD is safe and effective， and can improve cardiac function and platelet parameters， and prevent the occurrence of ischemic events.