OBJECTIVE： To investigate the effects of Compound puerarin tablet on the regeneration and apoptosis of liver cells in aged rats. METHODS： 40 rats were randomly divided into normal group， model group （normal saline， 10 ml/kg）， Compound puerarin tablet low-dose， medium-dose and high-dose groups [200， 400， 800 mg （crude drug）/kg]，8 for each group. Except for normal group， aging model was induced in those groups by irrigation gastric administration of D-galactose solution [250 mg/（kg·d）] at 9 o’clock every morning； they were given relevant medicine at 15 o’clock every afternoon， ig， for 8 weeks. The contents of SOD and MDA in serum and liver， and the content of hepatic lipofuscin （LPF） in liver were determined by related kit operation procedure； the pathological change of liver tissue was observed in rats. RESULTS： Compared with normal group， the activity of SOD in serum and liver decreased significantly in model group， while the contents of MDA and LPF increased significantly （P＜0.01）； the number of leukomonocyte in liver of rats increased significantly， and scattered apoptotic cells increased； lymphocyte periportal focal and scattered infiltration of hepatic sinusoids were found in model group. Compared with model group， the activity of SOD in serum of rats increased significantly in Compound puerarin tablet low-dose and high-dose groups （P＜0.05 or P＜0.01）， while the content of MDA in serum of rats decreased significantly in medium-dose and high-dose groups （P＜0.01）； the content of SOD in liver tissue increased significantly in medium-dose and high-dose groups （P＜0.05 or P＜0.01）， while the contents of MDA and LPF in liver tissue decreased significantly in low-dose， medium-dose and high-dose groups （P＜0.05 or P＜0.01）； in low-dose， medium-dose and high-dose groups， the number of leukomonocyte decreased and apoptotic cells were rare， while the number of binucleate cells increased. CONCLUSIONS： Compound puerarin tablet can enhance liver cell regeneration and reduce cell liver apoptosis in aged rats.