OBJECTIVE： To prepare Dry powder inhaler of curcumin-loaded solid lipid nanoparticles （Cur-SLN-DPI）. METHODS： With the particle size， polydispersity coefficient， encapsulation efficiency and drug deposition rate as the indexes， the Cur-SLN drying methods  （spray drying and freeze drying） were screened. Based on the optimized drying method， with the drug deposition rate， emptying rate， the angle of repose， moisture-absorption weight gain rate and content uniformity as the indexes， single factor observation was made on the formulation of Cur-SLN-DPI （lactose-dry powder ratio， the filling amount of each single-dose capsule）， and verification tests were carried out. RESULTS： The rates of effective in vitro deposition of Cur-SLN obtained by spray and freeze drying were 29.98％ and 15.69％ respectively， and the former was better. The optimized single-dose formulation was as follows as lactose-dry powder （1 ∶ 1） mixture of 50 mg， lactose of 10 mg as the third component， in a No.4 capsule. The average values of all indexes of 3 lots of the prepared dry powder were as follows as particle size of 3.35 μm， 4.57％ of moisture， content uniformity represented as 3.65， effective in vitro deposition rate of 28.73％， emptying rate of 95.17％， the angle of repose of 24.03 ° and moisture-absorption weight gain rate of 2.2％ （RSD lower than 2％， n＝3）. CONCLUSIONS： It is suggested that Cur-SLN should be prepared by spray drying. The Cur-SLN-DPI prepared according to the optimized formulation conforms to quality standards.