OBJECTIVE： To evaluate the similarity of dissolution curves in vitro of Azelnidipine tablet between the self-prepared and original preparations， and provide reference for its quality control and clinical application. METHODS： Paddle method was used at rate of 50 r/min， and dissolution test was conducted with media of 500 ml pH1.2 Hydrochloric acid sodium chloride solution， pH4.0 Acetate buffer solution， pH6.8 Phosphate buffer solution， fiber-optic dissolution tester was used to detect the cumulative dissolution the main ingredients in Azelnidipine tablet between the self-prepared and original preparations at different time points， and compared with the results of UV-visible spectrophotometry， then dissolution curve was plotted， f2 was used to evaluate the similarity of their similarity. RESULTS： There was no obvious difference in the results between fiber optic drug dissolution real-time detector and UV-visible spectrophotometry. f2 Similarity factors were more than 50 and the dissolution curves of the self-prepared and original preparations were similar in the different dissolution media， while the dissolution was relatively low in the last 3 media. CONCLUSIONS： Fiber-optic dissolution tester can accurately and conveniently provide the real-time dissolution and reflect its dynamic dissolution process， which provides an effective way to investigate the inner quality of drug completely. However， the formulation and technology of the self-prepared preparation of Azelnidipine tablet need to be further studied.