OBJECTIVE： To observe the effects and safety of octreotide acetate after pediatric acute abdomen surgery. METHODS： 130 children with acute abdomen were selected and randomly divided into observation group and control group， with 65 cases in each group. Control group was given Ceftriaxone sodium for injetion 50 mg/kg， iv， qd； after surgery to maintain water-electrolyte balance. Observation group was additionally given continuous pump of Octreotide acetate injection 0.01 mg/（kg·d），ivgtt （immediately after surgery）， for 1-3 d， on the basis of control group. The intra-abdominal pressure， the time of gastrointestinal function recovery， TNF-α level， liver/renal function index and blood/urine amylase were observed in 2 groups， and the occurrence of ADR was recorded. RESULTS： The total effective rate of observation group （98.5％） was significantly higher than that of control group （92.3％）， with statistical significance （P＜0.05）. On 3rd and 5th day after surgery， intra-abdominal pressure， the levels of TNF-α and blood/urine amylase were decreased significantly， compared to before surgery； the indexes of observation group were lower than that of control group， and the recovery of gastrointestinal function in observation group was significantly better than in control group， with statistical significance （P＜0.05）. There was no statistical significance in liver and renal function indexes between 2 groups before and after surgery （P＞0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： For pediatric acute abdomen， octreotide acetate can effectively reduce intra-abdominal pressure， the levels of TNF-α and blood/urine amylase， and improve gastrointestinal function with good safety